Hydrochloric Acid → HCID 66755803, compound

HRID 1643091Notes

Reaction equation

HRID 1643091 reaction equation
[ClH:1].[CH3:2][N:3]([CH2:11][C:12]1[O:16][N:15]=[C:14]([CH:17]2[CH2:22][CH:21]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)[CH2:20][N:19]([C:33]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[O:34])[CH2:18]2)[N:13]=1)C(=O)OC(C)(C)C>O1CCOCC1>[ClH:1].[CH3:2][NH:3][CH2:11][C:12]1[O:16][N:15]=[C:14]([CH:17]2[CH2:22][CH:21]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:30])[F:31])=[CH:25][CH:24]=3)[CH2:20][N:19]([C:33]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[O:34])[CH2:18]2)[N:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58002720HCID 58002720, compound

Product 1

HCID 66755803HCID 66755803, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.43 ml (1.73 mmol) of a 4N solution of hydrogen chloride in dioxane was added to a solution of 96 mg (0.17 mmol) of the compound from Example 90A in 0.8 ml of dioxane, and the mixture was stirred at room temperature for 24 h. The reaction mixture was then concentrated under reduced pressure, dichloromethane was added and the mixture was concentrated again. Yield: 85 mg (99% of theory).

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure, dichloromethane
  2. additionwas added
  3. concentrationthe mixture was concentrated again

Sources & evidence

ORD record
ord-41aaec2314ba4ecdb0d038e6b1398ad0
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

Loading…