Hydrochloric Acid → HCID 66755328, compound

HRID 1643121Notes

Reaction equation

HRID 1643121 reaction equation
[ClH:1].[N:2]1([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[CH2:13][CH:12]([C:26]3[N:30]=[C:29]([C@@H:31]4[CH2:35][CH2:34][CH2:33][N:32]4C(OC(C)(C)C)=O)[O:28][N:27]=3)[CH2:11]2)=[O:9])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1>O1CCOCC1>[ClH:1].[N:2]1([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:23])([F:25])[F:24])=[CH:18][CH:17]=3)[CH2:13][CH:12]([C:26]3[N:30]=[C:29]([CH:31]4[CH2:35][CH2:34][CH2:33][NH:32]4)[O:28][N:27]=3)[CH2:11]2)=[O:9])[CH2:3][CH2:4][O:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58002128HCID 58002128, compound

Product 1

HCID 66755328HCID 66755328, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.36 ml (1.46 mmol) of a 4N solution of hydrogen chloride in dioxane was added to a solution of 84 mg (0.146 mmol) of the compound from Example 91A in 0.7 ml of dioxane, and the mixture was stirred at room temperature for 20 hours. The reaction mixture was then concentrated under reduced pressure, dichloromethane was added and the mixture was concentrated again. Yield: 74 mg (98% of theory).

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure, dichloromethane
  2. additionwas added
  3. concentrationthe mixture was concentrated again

Sources & evidence

ORD record
ord-4317e9b9fad640e8b7de7a43d7ba656f
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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