Isopropylamine → HCID 58002672, compound

HRID 1643132Notes

Reaction equation

[CH:1]([NH2:4])([CH3:3])[CH3:2].C(N(CC)CC)C.Cl[CH2:13][C:14]1[N:15]=[C:16]([CH:19]2[CH2:24][CH:23]([C:25]3[CH:30]=[CH:29][C:28]([CH2:31][CH3:32])=[CH:27][CH:26]=3)[CH2:22][N:21]([C:33]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[O:34])[CH2:20]2)[S:17][CH:18]=1>CN1CCCC1=O>[CH2:31]([C:28]1[CH:27]=[CH:26][C:25]([CH:23]2[CH2:24][CH:19]([C:16]3[S:17][CH:18]=[C:14]([CH2:13][NH:4][CH:1]([CH3:3])[CH3:2])[N:15]=3)[CH2:20][N:21]([C:33]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[O:34])[CH2:22]2)=[CH:30][CH:29]=1)[CH3:32]

Participants

Conditions

Temperature: 80 °C

Procedure

24 mg (0.411 mmol) of isopropylamine and 70 mg (0.685 mmol) of triethylamine were added to a solution of 119 mg (0.274 mmol) of the compound from Example 141A in 2 ml of N-methylpyrrolidone. The reaction mixture was stirred at 80° C. overnight and, without any further work-up, purified by preparative HPLC. Yield: 10 mg (8% of theory)

Workup

custompurified by preparative HPLC

Sources & evidence

ORD record: ord-e79e9bb307ea481184c18d759b4c7c74
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119663B2

Reaction notes

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