Trifluoroacetic acid → HCID 59568786, compound

HRID 1643294Notes

Reaction equation

HRID 1643294 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([O:30][CH3:31])[CH2:9][C@@H:10]([C:26]([O:28][CH3:29])=[O:27])[CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([O:30][CH3:31])[CH2:9][C@H:10]([CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[C:26]([O:28][CH3:29])=[O:27])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59568806HCID 59568806, compound

Product 1

HCID 59568786HCID 59568786, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of tert-butyl 4-((3S,5R)-5-(4-fluorophenyl)-5-methoxy-3-(methoxycarbonyl)pentyl)piperazine-1-carboxylate in 200 μL DCM was slowly added 2 mL TFA and the resulting solution stirred for 30 min at 25° C. The solvent was evaporated under reduced pressure and the crude product was used directly in the next reaction without further purification.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe crude product was used directly in the next reaction without further purification

Sources & evidence

ORD record
ord-1fe13399ed514420a0eab174696ecc84
Source dataset
uspto-grants-2012_02
Patent number
US08119692B2

Reaction notes

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