Hydrochloric Acid → HCID 59568807, compound

HRID 1643301Notes

Reaction equation

HRID 1643301 reaction equation
[CH3:1][O:2][CH:3]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17])[CH2:4][CH2:5][CH:6]1OCC[O:7]1.Cl.O>C1COCC1>[CH3:1][O:2][CH:3]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17])[CH2:4][CH2:5][CH:6]=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 59568838HCID 59568838, compound

Product 1

HCID 59568807HCID 59568807, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-(3-Methoxy-3-o-tolyl-propyl)-[1,3]dioxolane (285.0 mg, 1.2 mmol) in 14 mL THF was added 7 mL 1M aqueous HCl at room temperature. After stirring the mixture for 12 h, water was added and the solution extracted with ethyl acetate (3×20 mL). The combined organic layers were washed with brine (2×10 mL) and dried over Na2SO4. Evaporation of solvent provided the desired product as an oil which was used directly in the next experiment without further purification.

Workup

  1. extractionthe solution extracted with ethyl acetate (3×20 mL)
  2. washThe combined organic layers were washed with brine (2×10 mL)
  3. dry with materialdried over Na2SO4
  4. customEvaporation of solvent

Sources & evidence

ORD record
ord-53b4d6844a7c41f3ad03667c54eca3ae
Source dataset
uspto-grants-2012_02
Patent number
US08119692B2

Reaction notes

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