Thionyl Chloride → HCID 77174849, compound

HRID 1643336Notes

Reaction equation

HRID 1643336 reaction equation
[Br:1][C:2]1[C:3]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:4][C:5]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:29])=O>CN(C=O)C>[Br:1][C:2]1[C:3]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:4][C:5]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([CH:10]=1)[C:7]([Cl:29])=[O:8]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 469156382,4-Bis(benzyloxy)-5-bromobenzoic acid

Product 1

HCID 77174849HCID 77174849, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Procedure

1.4 9 g of 5-bromo-2,4-dibenzyloxybenzoic acid, 40 ml of thionyl chloride and 1 drop of DMF are stirred at room temperature for 4 hours. The thionyl chloride is removed, and the residue is treated twice with dichloromethane, giving 9.4 g of 5-bromo-2,4-dibenzyloxybenzoyl chloride, which is processed further directly.

Workup

  1. customThe thionyl chloride is removed
  2. additionthe residue is treated twice with dichloromethane

Sources & evidence

ORD record
ord-0ed69b3e5b3c4b8fb8345c2ebf4e322d
Source dataset
uspto-grants-2012_02
Patent number
US08119795B2

Reaction notes

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