Methanol → HCID 178424333, compound

HRID 1643339Notes

Reaction equation

HRID 1643339 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([O:15]CC2C=CC=CC=2)[C:12](Br)=[CH:11][C:10]=1[C:24]1[N:25]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[CH3:36])[C:26]([OH:29])=[N:27][N:28]=1)C1C=CC=CC=1.C[OH:38].[C]=O.[CH2:41]([N:43]([CH2:46]C)[CH2:44][CH3:45])C.[C:48]1(C)C=[CH:52][CH:51]=[CH:50][CH:49]=1>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[OH:8][C:9]1[CH:14]=[C:13]([OH:15])[C:12]([C:46]([N:43]([CH2:44][C:45]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)[CH3:41])=[O:38])=[CH:11][C:10]=1[C:24]1[N:25]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[CH3:36])[C:26]([OH:29])=[N:27][N:28]=1

Participants

7

Reactant 5

HCID 887MethanolHCID 1140TolueneHCID 8471TriethylamineHCID 178418416HCID 178418416, compoundHCID 178424332HCID 178424332, compound

Product 1

HCID 178424333HCID 178424333, compound

Reagents, catalysts & solvents 1

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)Catalyst

Procedure

7.3 g of 5-(2,4-dibenzyloxy-5-bromophenyl)-4-(2-methylphenyl)-3-hydroxy-4H-1,2,4-triazole, 150 ml of methanol, 0.3 l of carbon monoxide, 150 mg of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), 2 g of triethylamine and 10 ml of toluene.

Sources & evidence

ORD record
ord-febdc58c96804ae0825e53f1c5691181
Source dataset
uspto-grants-2012_02
Patent number
US08119795B2

Reaction notes

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