Hydrochloric Acid → HCID 66756432, compound

HRID 1643364Notes

Reaction equation

HRID 1643364 reaction equation
[ClH:1].[CH3:2][O:3][C:4](=[O:26])[CH2:5][N:6]1[C:12](=[O:13])[C@@H:11]([NH:14]C(OC(C)(C)C)=O)[CH2:10][NH:9][C:8]2[CH:22]=[CH:23][CH:24]=[CH:25][C:7]1=2>C(OCC)(=O)C>[ClH:1].[CH3:2][O:3][C:4](=[O:26])[CH2:5][N:6]1[C:12](=[O:13])[C@@H:11]([NH2:14])[CH2:10][NH:9][C:8]2[CH:22]=[CH:23][CH:24]=[CH:25][C:7]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54305289(3S)-2-Oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester

Product 1

HCID 66756432HCID 66756432, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Anhydrous hydrogen chloride was bubbled into a solution of (3(S)-tert-butoxycarbonylamino-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)acetic acid methyl ester (103, 1 g, 2.86 mmol) in 25 ml of ethyl acetate for 2 minutes then stirred for 1 hour at room temperature. The reaction was evaporated to give 2-oxo-3(S)-amino-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl acetic acid methyl ester hydrochloride as a white solid.

Workup

  1. customThe reaction was evaporated

Sources & evidence

ORD record
ord-5b6b2ce58ff04b2ba989a370f3a9d48d
Source dataset
uspto-grants-2012_02
Patent number
US08119631B2

Reaction notes

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