Trifluoroacetic acid → HCID 59367776, compound

HRID 1643450Notes

Reaction equation

HRID 1643450 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([O:25][CH2:26][CH2:27][N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)[CH2:24][CH2:23][C:10]3([CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]3)[CH2:9][CH2:8]2)[CH:2]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([O:25][CH2:26][CH2:27][N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)[CH2:8][CH2:9][C:10]3([CH2:11][CH2:12][NH:13][CH2:14][CH2:15]3)[CH2:23][CH2:24]2)[CH:2]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67356290HCID 67356290, compound

Product 1

HCID 59367776HCID 59367776, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

tert-Butyl 9-(pyridin-3-yl)-9-(2-(pyrrolidin-1-yl)ethoxy)-3-azaspiro[5.5]undecane-3-carboxylate (0.33 mmol, 1 eq) was dissolved in methylene chloride (3.5 ml). TFA (0.7 ml) was added at 0° C. and the mixture was stirred at 25° C. for 1 h. The solvent was concentrated to dryness under reduced pressure and the resulting desired product was employed in the next stage without further purification.

Workup

  1. concentrationThe solvent was concentrated to dryness under reduced pressure
  2. customthe resulting desired product was employed in the next stage without further purification

Sources & evidence

ORD record
ord-483bedf81f934c979dc25971a995b68a
Source dataset
uspto-grants-2012_02
Patent number
US08119805B2

Reaction notes

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