HCID 59367762, compound → HCID 57819729, compound

HRID 1643472Notes

Reaction equation

HRID 1643472 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]2/[CH:19]=[CH:20]/[C:21]([O:23][CH2:24][CH3:25])=[O:22])(=[O:12])=[O:11])=[C:5]([CH3:26])[CH:4]=1>CO.[OH-].[OH-].[Pd+2]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH3:26])[C:6]([S:10]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]2[CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])(=[O:11])=[O:12])=[C:7]([CH3:9])[CH:8]=1

Participants

4

Reactant 1

HCID 59367762HCID 59367762, compound

Product 1

HCID 57819729HCID 57819729, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A degassed solution of (E)-ethyl 3-(1-(4-methoxy-2,6-dimethylphenylsulfonyl)-piperidin-2-yl)acrylate (4.19 mmol) in MeOH was hydrogenolysed with Pd(OH)2 (0.4 g) as the catalyst. The resulting crude product was employed in the following stage without further purification.

Workup

  1. customThe resulting crude product was employed in the following stage without further purification

Sources & evidence

ORD record
ord-b705a966210f4f2b83c8fd4932187d8e
Source dataset
uspto-grants-2012_02
Patent number
US08119805B2

Reaction notes

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