Hydrochloric Acid → HCID 57916255, compound

HRID 1643476Notes

Reaction equation

HRID 1643476 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][OH:8].C(N(CC)CC)C.[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:18]=1[S:24](Cl)(=[O:26])=[O:25].Cl>C(Cl)Cl>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:18]=1[S:24]([N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][OH:8])(=[O:25])=[O:26]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 94263Piperidin-2-ylmethanolHCID 157253702-Chloro-6-methylbenzene-1-sulfonyl chloride

Product 1

HCID 57916255HCID 57916255, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Piperidin-2-yl-methanol (17.39 mmol, 1 eq) was dissolved in methylene chloride (20 ml) and triethylamine (43.47 mmol, 2.5 eq) at 0° C. and a solution of 2-chloro-6-methyl-benzenesulfonyl chloride (17.39 mmol, 1 eq) in methylene chloride (65 ml) was added dropwise. The reaction solution was stirred at room temperature for 90 min. 0.5 M HCl (75 ml) was then added and the mixture was stirred for a further 15 min. The organic phase was washed with water (10 ml), dried over sodium sulfate and concentrated to dryness under reduced pressure. Yield: 90%

Workup

  1. stirringthe mixture was stirred for a further 15 min
  2. washThe organic phase was washed with water (10 ml)
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-38fbca5f66484d9ab0d88a9883a33e62
Source dataset
uspto-grants-2012_02
Patent number
US08119805B2

Reaction notes

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