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HRID1644318

反应详情

EQUATION

反应方程式

HRID 1644318 的结构方程式

REACTANTS

反应物

4
结构：OCCBr
HCID10898

2-Bromo-1-ethanol

C2H5BrO

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：COC(=O)[C@H]1CNCC[C@H]1NC(=O)OCc1ccccc1
HCID58999552

未命名化合物

结构：COC(=O)[C@H]1CN(CCO)CC[C@H]1NC(=O)OCc1ccccc1
HCID66774341

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CN(CCO)CC[C@H]1NC(=O)OCc1ccccc1
HCID66775250

未命名化合物

收率 60%

PROCEDURE

实验过程

Methyl(3S,4R)-4-{[(benzyloxy)carbonyl]amino}piperidine-3-carboxylate (WO 2005/066176) (2.0 g, 6.84 mmol), N,N-diisopropylethylamine (1.8 mL, 10.26 mmol) and 2-bromoethanol (0.63 mL, 8.9 mmol) were reacted as described for Intermediate 37 to give 1.38 g (60%) of the product as a colorless oil.