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HRID1644624

反应详情

EQUATION

反应方程式

HRID 1644624 的结构方程式

REACTANTS

反应物

3
反应SMILES：Nc1cccnc1N
HCID9956

2,3-Diaminopyridine

C5H7N3

反应SMILES：O=C(O)c1cccc(NS(=O)(=O)c2cccs2)c1
HCID800088

3-[(2-Thienylsulfonyl)amino]benzoic acid

C11H9NO4S2

反应SMILES：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID2733084

Methanaminium, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, hexafluorophosphate(1-) (1:1)

C11H16F6N5OP

PRODUCTS

产物

1
反应SMILES：O=S(=O)(Nc1cccc(-c2nc3ncccc3[nH]2)c1)c1cccs1
HCID59243189

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CN(C)C=O
溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

3-(thiophene-2-sulfonamido)benzoic acid (242b) was reacted with 2,3-diaminopyridine, HBTU and TEA in DMF followed by microwave as described previously for example 235. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.74 (s, 1H), 8.45 (d, 1H, J=4.6 Hz), 8.20 (d, 1H, J=7.3 Hz), 8.11 (m, 1H), 7.92 (m, 2H), 7.61 (dd, 1H, J=1.4, 3.7 Hz), 7.52 (t, 2H, J=8.0 Hz), 7.40 (dd, 1H, J=5.0, 7.8 Hz), 7.33 (dd, 1H, J=1.3, 8.0 Hz), 7.12 (dd, 1H, J=3.8, 5.0 Hz); Calc'd for C16H12N4O2S2; (M+H)=357; found 357.