Hydrochloric Acid → HCID 57329642, compound

HRID 1644769Notes

Reaction equation

HRID 1644769 reaction equation
Cl.C([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:23])[NH:13][C:14]2[S:15][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:17][N:18]=2)=[CH:8][CH:7]=1)(=O)C>O1CCCC1>[OH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([NH:13][C:14]2[S:15][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:17][N:18]=2)=[O:23])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57329640HCID 57329640, compound

Product 1

HCID 57329642HCID 57329642, compoundYield 64.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2 M hydrochloric acid (45.0 mL) was added to a suspension of 78 (0.439 g, 1.29 mmol) in tetrahydrofuran (20.0 mL), and the suspension was warmed to reflux. The reaction became homogeneous upon heating. After refluxing for 4 hours, the reaction was allowed to cool to room temperature, and stood at room temperature overnight before the reaction was filtered. The filter pad was washed with water then dried in vacuo at 70° C. to give 80 (0.2489 g, 64.6%) as a white crystalline solid.

Workup

  1. temperaturethe suspension was warmed to reflux
  2. temperatureupon heating
  3. temperatureAfter refluxing for 4 hours
  4. filtrationwas filtered
  5. washThe filter pad was washed with water
  6. customthen dried in vacuo at 70° C.

Sources & evidence

ORD record
ord-2d1129d90bc841a49f5dfad57dbfcfb6
Source dataset
uspto-grants-2012_02
Patent number
US08124632B2

Reaction notes

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