Hydrochloric Acid → HCID 25154341, compound

HRID 1644772Notes

Reaction equation

HRID 1644772 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:22])[NH:12][C:13]1[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][N:17]=1)(=O)C.Cl>C1COCC1>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:12][C:13]1[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][N:17]=1)=[O:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 251886012-(Acetyloxy)-N-[5-(methylsulfonyl)-2-thiazolyl]benzamide

Product 1

HCID 25154341HCID 25154341, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 7 (1.0 g, 2.94 mmol, 1.0 eq) dissolved in THF (20 mL) was added under stirring to 2M HCl (100 mL). The reaction was refluxed for one hour and allowed to cool under stirring over one hour. The product was filtered using a sintered glass funnel, washed with distilled water and THF and dried in high vacuum ato afford 834 mg (95%) of 6 as a colorless solid.

Workup

  1. additionwas added
  2. temperatureThe reaction was refluxed for one hour
  3. temperatureto cool
  4. filtrationThe product was filtered
  5. washwashed with distilled water and THF
  6. customdried in high vacuum ato

Sources & evidence

ORD record
ord-3750813336d04ea1988d86c9fdf3dd29
Source dataset
uspto-grants-2012_02
Patent number
US08124632B2

Reaction notes

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