Hydrochloric Acid → HCID 66773036, compound

HRID 1645340Notes

Reaction equation

HRID 1645340 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C@H:11]2[CH2:15][CH2:14][N:13](C(O)=O)[CH2:12]2)=[N:8][CH:9]=1)([O-:3])=[O:2].[ClH:19]>ClCCl.O1CCOCC1>[ClH:19].[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C@H:11]2[CH2:15][CH2:14][NH:13][CH2:12]2)=[N:8][CH:9]=1)([O-:3])=[O:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86642413HCID 86642413, compound

Product 1

HCID 66773036HCID 66773036, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

The above nitro compound (6.16 g, 20.0 mmol) was suspended in dichloromethane (200 mL) and hydrogen chloride in dioxane (4M, 25 mL) was added. The mixture was stirred overnight and solvents were evaporated to give (S)-5-nitropyridine-2-yl-pyrrolidine-3-yl-amine hydrochloride as an off white solid (5.92 g).

Workup

  1. customsolvents were evaporated

Sources & evidence

ORD record
ord-bb75c8d73186433d863d51c75edbcaea
Source dataset
uspto-grants-2012_02
Patent number
US08124766B2

Reaction notes

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