Ethyl Acetoacetate → 2-(6-Methyl-5,7-dioxaspiro[2.5]oct-6-yl)ethanol

HRID 1645591Notes

Reaction equation

[CH2:1]([C:4]1([CH2:10][CH2:11][OH:12])[O:9][CH2:8][CH2:7][CH2:6][O:5]1)CC.[C:13](OCC)(=O)[CH2:14]C(C)=O>>[CH3:1][C:4]1([CH2:10][CH2:11][OH:12])[O:5][CH2:6][C:7]2([CH2:14][CH2:13]2)[CH2:8][O:9]1

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 597924352-(2-Propyl-1,3-dioxan-2-yl)ethanol

Product 1

HCID 597924952-(6-Methyl-5,7-dioxaspiro[2.5]oct-6-yl)ethanolYield 36%

Procedure

The same procedure as in the steps (8a) and (8b) of Example 8, was repeated using ethyl acetoacetate and 1,1-bis(hydroxymethylcyclopropane) to obtain the title compound (2.9 g, total yield: 36%) as a light yellow oil.

Sources & evidence

ORD record: ord-993da1d13e5b4d82bcd4cb935eb86ead
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08124780B2

Reaction notes

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