Water → HCID 19738537, compound

HRID 1646034Notes

Reaction equation

HRID 1646034 reaction equation
Cl[CH:2]([CH3:5])[CH:3]=[CH2:4].[CH3:6][O:7][CH:8]([O:16][CH3:17])[CH2:9][NH:10][C:11](=[O:15])[O:12][CH2:13][CH3:14].[OH-].[K+].O>CN(C)C=O>[CH2:4]=[CH:3][CH:2]([N:10]([CH2:9][CH:8]([O:7][CH3:6])[O:16][CH3:17])[C:11](=[O:15])[O:12][CH2:13][CH3:14])[CH3:5]

Participants

6

Reactant 4

HCID 962WaterHCID 112423-Chloro-1-buteneHCID 14797Potassium HydroxideHCID 10921057Ethyl 2,2-dimethoxyethylcarbamate

Product 1

HCID 19738537HCID 19738537, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

22 g (0.24 mol) of 3-chloro-1-butene are added to 35.5 g (0.2 mol) of ethyl N-(2,2-dimethoxyethyl)-carbamate and 26 g of powdered potassium hydroxide in 400 ml of dimethylformamide and the mixture is warmed overnight to 40° C. The salts are dissolved with water and the mixture is extracted several times with methylene chloride. The organic extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

Workup

  1. temperaturethe mixture is warmed overnight to 40° C
  2. extractionthe mixture is extracted several times with methylene chloride
  3. dry with materialThe organic extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

Sources & evidence

ORD record
ord-73c831a286ef4e12b6e586ef2141c8bd
Source dataset
uspto-grants-1993_01
Patent number
US05177210

Reaction notes

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