Trifluoroacetic acid → 2-(3-Bromo-phenyl)-6-chloro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester
Reaction equation
[CH2:26]([SiH:27]([CH2:28][CH3:29])[CH2:30][CH3:31])[CH3:32].[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([Cl:25])[cH:8][c:9]2[c:14]1[NH:13][CH:12]([c:15]1[cH:16][c:17]([Br:21])[cH:18][cH:19][cH:20]1)[C:11]([CH3:22])([CH3:23])[CH:10]2[OH:24].[OH:33][C:34]([C:35]([F:36])([F:37])[F:38])=[O:39]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([Cl:25])[cH:8][c:9]2[c:14]1[NH:13][CH:12]([c:15]1[cH:16][c:17]([Br:21])[cH:18][cH:19][cH:20]1)[C:11]([CH3:22])([CH3:23])[CH2:10]2Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-b2f807cb16664189a8abc0a460deaaab
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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