4-Amino-6-methyl-2,5-dihydro-1,2,4-triazin-3-one → HCID 54162271, compound

HRID 1646172Notes

Reaction equation

HRID 1646172 reaction equation
[O:1]=[C:2]1[N:7]([NH2:8])[CH2:6][C:5]([CH3:9])=[N:4][NH:3]1.[CH3:10][C:11]1[C:16]([CH:17]=O)=[CH:15][CH:14]=[CH:13][N:12]=1>C(O)C.Cl>[O:1]=[C:2]1[N:7]([N:8]=[CH:17][C:16]2[C:11]([CH3:10])=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]([CH3:9])=[N:4][NH:3]1

Participants

5

Reactant 2

HCID 109755004-Amino-6-methyl-2,5-dihydro-1,2,4-triazin-3-oneHCID 110838812-Methylpyridine-3-carbaldehyde

Product 1

HCID 54162271HCID 54162271, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 702EthanolSolvent

Procedure

To a solution of 0.5 g (4 mmol) of 2,3,4,5-tetrahydro-3-oxo-4-amino-6-methyl-1,2,4-triazine in 250 ml of ethanol are added, at room temperature, 0.48 g (4 mmol) of 2-methylpyridine-3-carbaldehyde and 1 drop of concentrated HCl. The reaction mixture is stirred for 1/2 hour and then filtered. The isolated solid is washed with ether and dried, affording the title compound of formula ##STR26## in the form of a colourless solid; m.p. 226°-229° C. (yield: 0.6 g; 64%).

Workup

  1. filtrationfiltered
  2. washThe isolated solid is washed with ether
  3. customdried

Sources & evidence

ORD record
ord-0be0ac8f0e604a78be6dab5e0e3cfe85
Source dataset
uspto-grants-1993_01
Patent number
US05179094

Reaction notes

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