Hydrochloric Acid → N-[[2-(Phosphonomethyl)phenyl]methyl]glycine, hydrochloride

HRID 1646179Notes

Reaction equation

HRID 1646179 reaction equation
C([O:3][P:4]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][NH:17][CH2:18][C:19]([O:21]C)=[O:20])([O:6]CC)=[O:5])C.[ClH:23]>>[ClH:23].[P:4]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][NH:17][CH2:18][C:19]([OH:21])=[O:20])([OH:6])([OH:5])=[O:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19801611HCID 19801611, compound

Product 1

HCID 85635052N-[[2-(Phosphonomethyl)phenyl]methyl]glycine, hydrochloride

Procedure

A solution of methyl N-[[2[(diethoxyphosphinyl)methyl]phenyl]methyl]glycinate (Example 1) (0.5 g, 1.5 mmol) in 6N hydrochloric acid solution (10 ml) is stirred at reflux in an oil bath for 18 hours. The water is removed in vacuo to give 0.4 g of a white solid.

Workup

  1. temperatureat reflux in an oil bath for 18 hours
  2. customThe water is removed in vacuo

Sources & evidence

ORD record
ord-3cbc00c8eb004dacb065bb8bafcc3c18
Source dataset
uspto-grants-1993_01
Patent number
US05179085

Reaction notes

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