Acetonitrile → HCID 15106923, compound

HRID 1646192Notes

Reaction equation

HRID 1646192 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]1=2)=[O:3].CC[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29].C([N:32]([CH2:35]C)CC)C.C(#[N:39])C>>[CH3:35][N:32]1[CH:24]2[CH2:25][CH2:26][CH:27]1[CH:28]1[CH:23]2[CH2:22][N:39]([C:2]([N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[NH:7][C:6]3[CH:16]=[CH:17][CH:18]=[CH:19][C:5]2=3)=[O:3])[CH2:29]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 15600DecaneHCID 132767455-chlorocarbonyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Product 1

HCID 15106923HCID 15106923, compoundYield 30%

Procedure

Prepared analogously to Example 14 from 1.40 g (5.1 mmoles) of 5-(chlorocarbonyl)-5,10-dihydro-11H-dibenzo [b,e][1,4]diazepin-11-one, 0.78 g (5.12 mmoles) of 10-methyl-4,10- diazatricyclo[5.2.1.0z.° ]decane, 0.7 ml (5.1 mmoles) of triethylamine and 60 ml of acetonitrile in a yield of 30% of theory.

Sources & evidence

ORD record
ord-03f32d49d3c64d05a8dcddcc1545bd07
Source dataset
uspto-grants-1993_01
Patent number
US05179090

Reaction notes

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