Dimethylformamide dimethyl acetal → HCID 14473602, compound

HRID 1646254Notes

Reaction equation

HRID 1646254 reaction equation
[NH2:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][CH3:9])[N:4]=1.CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[CH2:8]([C:5]1[N:4]=[C:3]([CH2:2][N:1]=[CH:12][N:13]([CH3:15])[CH3:14])[O:7][N:6]=1)[CH3:9]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 10820904(3-ethyl-1,2,4-oxadiazol-5-yl)methanamine

Product 1

HCID 14473602HCID 14473602, compoundYield 74.8%

Procedure

A mixture of 26 g of 5-aminomethyl-3-ethyl-1,2,4-oxadiazole and 30 ml of dimethylformamide dimethylacetal is heated for 6 1/2 hours to 80° C. (bath temperature). Subsequently, 16 ml of methanol is removed by distillation and the resultant product is purified by bulb tube distillation, thus obtaining 27.9 g (74.8%) of an oil having a boiling point of 130-150° C. (0.05 torr); nD20 :1.4924.

Workup

  1. temperatureis heated for 6 1/2 hours to 80° C. (bath temperature)
  2. customSubsequently, 16 ml of methanol is removed by distillation
  3. customthe resultant product is purified by bulb tube
  4. distillationdistillation

Sources & evidence

ORD record
ord-fd45ad05f0414532854ceb6b935c7241
Source dataset
uspto-grants-1993_01
Patent number
US05179111

Reaction notes

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