Dimethyl Sulfoxide → tert-butyl N-[1-[1-(3-amino-1-cyclopropyl-6-fluoro-8-methyl-2,4-dioxoquinazolin-7-yl)pyrrolidin-3-yl]ethyl]carbamate
Reaction equation
[C:20]([CH3:21])([CH3:22])([CH3:23])[O:24][C:25]([NH:26][CH:27]([CH3:28])[CH:29]1[CH2:30][NH:31][CH2:32][CH2:33]1)=[O:34].[CH2:42]1[CH2:43][NH:44][CH2:45][CH2:46]1.[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH3:48][S:49](=[O:50])[CH3:51].[NH2:1][n:2]1[c:3](=[O:19])[n:4]([CH:16]2[CH2:17][CH2:18]2)[c:5]2[c:6]([CH3:15])[c:7]([F:14])[c:8]([F:13])[cH:9][c:10]2[c:11]1=[O:12].[OH2:47]>>[NH2:1][n:2]1[c:3](=[O:19])[n:4]([CH:16]2[CH2:17][CH2:18]2)[c:5]2[c:6]([CH3:15])[c:7]([N:31]3[CH2:30][CH:29]([CH:27]([NH:26][C:25]([O:24][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:34])[CH3:28])[CH2:33][CH2:32]3)[c:8]([F:13])[cH:9][c:10]2[c:11]1=[O:12]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-a36c664812fc42a9b2a6b2fda596fa9c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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