反应详情

温度

55 °C

A mixture of cyanomethyl 3-(t-butyloxycarbonylamino)benzoate (20 g), triethylamine (10.6 g), 4-dimethylaminopyridine (0.1 g) and benzyl alcohol (11.4 g) is stirred at a bath temperature of 55° C. for 15 hours. The reaction mixture is extracted with ethyl acetate (200 ml), and the extract is washed with water, and ethyl acetate is distilled off under reduced pressure. The residue is recrystallized from 80% aqueous acetonitrile solution to give the title compound (22.0 g, 93%) as white short needles.

1. extractionThe reaction mixture is extracted with ethyl acetate (200 ml)
2. washthe extract is washed with water, and ethyl acetate
3. distillationis distilled off under reduced pressure
4. customThe residue is recrystallized from 80% aqueous acetonitrile solution