反应详情

7.4 g of sodium cyanide, dissolved in 40 ml of water, and 18.0 g of phenyl acetaldehyde, dissolved in 30 ml of methanol, are added dropwise with ice-cooling to a mixture of 12.8 g of 1-amino-2,6-dimethylpiperidine, 60 ml of water and 8.6 ml of concentrated hydrochloric acid. The reaction mixture is stirred at room temperature for 3 days and extracted with dichloromethane. The combined organic phases are washed with water of pH 4-5 containing acetic acid, dried and concentrated in a rotary evaporator. 32.5 g of 2-((2,6-dimethylpiperidino)amino)-3-phenylpropionitrile are obtained, which are reacted further without further purification.

1. additionare added dropwise with ice-
2. extractionextracted with dichloromethane
3. washThe combined organic phases are washed with water of pH 4-5
4. additioncontaining acetic acid
5. customdried
6. concentrationconcentrated in a rotary evaporator