N-methyl-2-pyrrolidone → HCID 15158253, compound

HRID 1646400Notes

Reaction equation

HRID 1646400 reaction equation
CN1CCCC1=O.[CH:8]1[C:20]2[N:19]([NH2:21])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]=2[CH:11]=[CH:10][CH:9]=1.[Cl:22][C:23]1[CH:28]=[C:27](Cl)[N:26]=[CH:25][N:24]=1>O>[Cl:22][C:23]1[N:24]=[CH:25][N:26]=[C:27]([NH:21][N:19]2[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[C:12]3[C:20]2=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH:28]=1

Participants

5

Reactant 3

HCID 13387N-methyl-2-pyrrolidoneHCID 709434,6-DichloropyrimidineHCID 2762079H-carbazol-9-amine

Product 1

HCID 15158253HCID 15158253, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

To 150 ml of 1-methyl-2-pyrrolidinone was added 10.0 g of 9H-carbazol-9-amine, and 8.2 g of 4,6-dichloropyrimidine, and the mixture was heated to 100° C. and stirred for eleven hours. The mixture was then poured into water and extracted with toluene. The organic layer was washed with water and dried (sat. NaCl, anhydrous MgSO4).

Workup

  1. extractionextracted with toluene
  2. washThe organic layer was washed with water
  3. dry with materialdried (sat. NaCl, anhydrous MgSO4)

Sources & evidence

ORD record
ord-c3daedecd5fa4c1fbddc27c3859b9f1c
Source dataset
uspto-grants-1993_01
Patent number
US05179204

Reaction notes

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