反应详情

5.9 g of 1-hydroxy-4-indanecarbonitrile in 60 ml of 1,2,-dichloroethane and 210 mg of paratoluene sulphonic acid (APTS, 1H2O) are taken to reflux for 2 hours. After cooling to ambient temperature and concentrating to dryness at 40° C. under reduced pressure, the residue is chromatographed on silica in a hexane-isopropyl ether mixture (9-1), and 2.46 g of expected product is isolated.

1. temperatureto reflux for 2 hours
2. concentrationconcentrating to dryness at 40° C. under reduced pressure
3. customthe residue is chromatographed on silica in a hexane-isopropyl ether mixture (9-1)