反应详情

温度

100 °C

To a solution of 2-(3-methylindol-2-yl)ethylamine (1.74 g) in tetrahydrofuran (200 ml) at room temperature was added 1,1'-carbonyldiimidazole (1.6 g) in small portions. After one hour of stirring, the reaction mixture was evaporated in vacuo. The residue was dissolved in toluene and the solution was evaporated in vacuo. The oil obtained was heated at 100° C. for 40 minutes and then cooled. Purification of the residue with silica gel column chromatography (chloroform) gave 3,4-dihydro-5-methylpyrimido[1,6-a]indol-1(2H)-one (0.8 g).

1. customthe reaction mixture was evaporated in vacuo
2. dissolutionThe residue was dissolved in toluene
3. customthe solution was evaporated in vacuo
4. customThe oil obtained
5. temperaturecooled
6. customPurification of the residue with silica gel column chromatography (chloroform)