HCID 10375132, compound → HCID 10465095, compound

HRID 1646762Notes

Reaction equation

HRID 1646762 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([CH3:14])([CH3:13])[C:11]#[N:12].N.CO>[Rh]>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([CH3:14])([CH3:13])[CH2:11][NH2:12]

Participants

4

Reactant 2

HCID 10375132HCID 10375132, compoundHCID 21705897Ammonia methanol

Product 1

HCID 10465095HCID 10465095, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 23948RhodiumCatalyst

Procedure

A mixture of 2-(indol-2-yl)-2-methylpropiononitrile (300 mg) and 5% rhodium on alumina powder (500 mg) in 10N-ammonia-methanol was hydrogenated at 50-60 psi for 8 hours. After filtration of the catalyst, the filtrate was evaporated in vacuo to give 2-(indol-2-yl)-2-methylpropylamine (306 mg) as crystals.

Workup

  1. filtrationAfter filtration of the catalyst
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-94bf6d25f65f409a89d6d2424220786e
Source dataset
uspto-grants-1993_01
Patent number
US05180728

Reaction notes

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