Water → HCID 14209230, compound

HRID 1646849Notes

Reaction equation

HRID 1646849 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][CH2:14][CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[OH:16].C(N(CC)CC)C.O>C(OC(O)C)C>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:13][CH2:14][CH:15]([OH:16])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 962WaterHCID 1000PhenylethanolamineHCID 68664,7-DichloroquinolineHCID 8471Triethylamine

Product 1

HCID 14209230HCID 14209230, compound

Reagents, catalysts & solvents 1

HCID 101298981-EthoxyethanolSolvent

Procedure

A solution of 4,7-dichloroquinoline (19.8 g), 2-amino-1-phenylethanol (13.7 g) and 20 ml of triethylamine (14.5 g) in 10 ml of ethoxyethanol was heated at 130° C. overnight. The mixture was poured into 600 ml of water and the solid product was collected by filtration, recrystallized from ethoxyethanol and washed with ethanol. The yield was 16 g, mp 221°-222° C.

Workup

  1. filtrationthe solid product was collected by filtration
  2. customrecrystallized from ethoxyethanol
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-343a991c12e44c6998762a8b5d9b97c5
Source dataset
uspto-grants-1993_01
Patent number
US05182275

Reaction notes

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