Hydrogen Peroxide → HCID 86746509, compound

HRID 1646903Notes

Reaction equation

HRID 1646903 reaction equation
[O:1]=[C:2]([NH:14][NH:15][C:16]([N:18]1[CH2:24][C:23]2[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=2[S:21][C:20]2[CH:29]=[CH:30][C:31]([Cl:33])=[CH:32][C:19]1=2)=[O:17])[CH2:3][CH2:4][NH:5][C:6](=[O:13])[CH2:7][C:8]1[S:9][CH:10]=[CH:11][CH:12]=1.[OH:34]O>CC(O)=O>[O:1]=[C:2]([NH:14][NH:15][C:16]([N:18]1[CH2:24][C:23]2[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=2[S:21](=[O:34])[C:20]2[CH:29]=[CH:30][C:31]([Cl:33])=[CH:32][C:19]1=2)=[O:17])[CH2:3][CH2:4][NH:5][C:6](=[O:13])[CH2:7][C:8]1[S:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 86746510HCID 86746510, compound

Product 1

HCID 86746509HCID 86746509, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a stirring solution of 0.7 g (1.5 mmol) of 8-chlorodibenzo[b,f][1,4]thiazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-[(2-thienylacetyl)amino]propyl]hydrazide (37), prepared in the manner described above in Example 37, in 5 mL of HOAc is added 0.13 mL (1.5 mmol) of 30% H2O2. After stirring for 1 hour, the reaction mixture is lyophilized to obtain the product.

Workup

  1. customto obtain the product

Sources & evidence

ORD record
ord-88063116fc854d58aef232dbf605f680
Source dataset
uspto-grants-1993_01
Patent number
US05182272

Reaction notes

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