Tert-Butylamine → HCID 14880464, compound

HRID 1646944Notes

Reaction equation

HRID 1646944 reaction equation
[NH:1]1[C:9]2[C:4](=[C:5]([C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH:20]4[CH2:22][O:21]4)=[CH:14][CH:13]=3)=[O:11])[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[C:23]([NH2:27])([CH3:26])([CH3:25])[CH3:24]>C(O)C>[CH3:24][C:23]([NH:27][CH2:22][CH:20]([OH:21])[CH2:19][O:18][C:15]1[CH:14]=[CH:13][C:12]([C:10]([C:5]2[CH:6]=[CH:7][CH:8]=[C:9]3[C:4]=2[CH:3]=[CH:2][NH:1]3)=[O:11])=[CH:17][CH:16]=1)([CH3:26])[CH3:25]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 14880463HCID 14880463, compound

Product 1

HCID 14880464HCID 14880464, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4.65 g of the product of Step A, 100 ml of ethanol and 9.94 ml of tert-butylamine was stirred at reflux for 2 hours and the solution was distilled to dryness. The 6.83 g of residue were chromatographed on silica (eluant: ethyl acetate triethylamine (9-1)) to obtain 4.77 g of the desired product.

Workup

  1. temperatureat reflux for 2 hours
  2. distillationthe solution was distilled to dryness
  3. customThe 6.83 g of residue were chromatographed on silica (eluant: ethyl acetate triethylamine (9-1))

Sources & evidence

ORD record
ord-b210927d9aba45e0aade4b78de993c22
Source dataset
uspto-grants-1993_01
Patent number
US05182282

Reaction notes

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