Ethyl Acetate → HCID 86746515, compound

HRID 1646978Notes

Reaction equation

HRID 1646978 reaction equation
C(O[C:4]([CH2:6][C:7](=O)[CH2:8][O:9][N:10]=[C:11]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1)[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)=[O:5])C.Cl.[O:30]([NH2:32])[CH3:31].[C:33](OCC)(=[O:35])[CH3:34]>N1C=CC=CC=1>[CH2:33]([O:35][C:6](=[C:4]=[O:5])[C:7](=[N:32][O:30][CH3:31])[CH2:8][O:9][N:10]=[C:11]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[C:20]1[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=1)[CH3:34]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 140527694,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-oxopropyl)oxime

Product 1

HCID 86746515HCID 86746515, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3.85 g of the 4,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-oxopropyl) oxime as obtained in Example 1 was dissolved in 5 ml of pyridine and 1 g of methoxylamine hydrochloride was added thereto. Then the obtained mixture was stirred at room temperature. After two hours, the reaction mixture was poured into ethyl acetate, washed with diluted hydrochloric acid and then with a saturated saline solution and purified by silica gel chromatography. Thus 4 g of the title compound was obtained in the form of a colorless oily product.

Workup

  1. washwashed with diluted hydrochloric acid
  2. customwith a saturated saline solution and purified by silica gel chromatography

Sources & evidence

ORD record
ord-3854a08554fc4ea793719955829d5dc6
Source dataset
uspto-grants-1993_01
Patent number
US05182301

Reaction notes

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