Benzyl Bromide → HCID 19926181, compound

HRID 1647117Notes

Reaction equation

HRID 1647117 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:11]([OH:13])=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:20]([O:12][C:11](=[O:13])[CH:10]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 27559923-[(tert-Butoxycarbonyl)amino]-2-phenylpropanoic acid

Product 1

HCID 19926181HCID 19926181, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

N-(t-butoxycarbonyl)-2-phenyl-β-alanine was heated to reflux in acetone with benzyl bromide and potassium carbonate for 17 hours to yield DL-N-(t-butoxycarbonyl)-2-phenyl-β-alanine benzyl ester, m.p. 58°-59° C.

Sources & evidence

ORD record
ord-6eb59a06d2084345922805f2d5acf836
Source dataset
uspto-grants-1995_07
Patent number
US05430024

Reaction notes

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