Sodium hydride → HCID 19926603, compound

HRID 1647246Notes

Reaction equation

HRID 1647246 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[H-].[Na+].Br[C:11]1[S:15][C:14]([CH:16]=[O:17])=[CH:13][CH:12]=1>CN(C)C=O>[O:1]=[C:2]1[CH:7]=[CH:6][N:5]([C:11]2[S:15][C:14]([CH:16]=[O:17])=[CH:13][CH:12]=2)[CH:4]=[CH:3]1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 784285-Bromothiophene-2-carbaldehydeHCID 178418642HCID 178418642, compound

Product 1

HCID 19926603HCID 19926603, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

25.0 g of 4-hydroxypyridine was suspended in 440 ml of N,N-dimethylformamide. 11.04 g of sodium hydride (60% suspension in mineral oil) was added to the suspension in portions and the suspension was stirred for 1 h. 32.8 ml of 5-bromothiophene-2-carboxaldehyde was added thereto and a reaction was conducted at 120° C. for 4 h.

Workup

  1. waita reaction was conducted at 120° C. for 4 h.

Sources & evidence

ORD record
ord-4588661dcbd346c0ac43e7159420341f
Source dataset
uspto-grants-1995_07
Patent number
US05430059

Reaction notes

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