Trifluoroacetic acid → HCID 22068494, compound

HRID 1647337Notes

Reaction equation

HRID 1647337 reaction equation
[CH3:1][CH:2]([CH2:18][CH3:19])[CH:3]([NH:14]C(=O)O)[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)=[O:5].[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23]>C(Cl)Cl>[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23].[NH2:14][CH:3]([CH:2]([CH3:1])[CH2:18][CH3:19])[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 76412589HCID 76412589, compound

Product 1

HCID 22068494HCID 22068494, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 2.35 g of product from Example 1 in 10 ml of methylene chloride is added 2.8 ml of trifluoroacetic acid. The reaction is heated at 80°-90° C. for 41/2 hours and then concentrated in vacuo to give 3.6 g of the desired product as tris-trifluoroacetic acid salt.

Workup

  1. temperatureThe reaction is heated at 80°-90° C. for 41/2 hours
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-43256b58bc5b4173b025d1b611230fc9
Source dataset
uspto-grants-1995_07
Patent number
US05430150

Reaction notes

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