2-Pyridineethanamine → HCID 67781641, compound

HRID 1647340Notes

Reaction equation

HRID 1647340 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1.[C:10]([O:14][C:15]([NH:17][C@H:18]([C:23](O)=[O:24])[C@H:19]([CH2:21][CH3:22])[CH3:20])=[O:16])([CH3:13])([CH3:12])[CH3:11].F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.CCN(C(C)C)C(C)C>C(Cl)Cl>[CH3:11][C:10]([O:14][C:15](=[O:16])[NH:17][CH:18]([C:23]([NH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)=[O:24])[CH:19]([CH3:20])[CH2:21][CH3:22])([CH3:13])[CH3:12]

Participants

6

Reactant 4

HCID 759192-PyridineethanamineHCID 81531DiisopropylethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 2724762tert-Butoxycarbonyl-L-isoleucine

Product 1

HCID 67781641HCID 67781641, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared by the procedure of Example 1, using 1.0 g of 2-(2-amino-ethyl)pyridine, 2.163 g of N-(tert-butoxycarbonyl)-L-isoleucine, 6.15 g of BOP, 10.52 g of Hunig's base, and 15 ml of methylene chloride to give 2.5 g of the product as a white/yellow powder.

Sources & evidence

ORD record
ord-3509ac031f9741cfb0753fe09b0fce74
Source dataset
uspto-grants-1995_07
Patent number
US05430150

Reaction notes

Loading…