4-Aminobenzyl alcohol → HCID 178450496, compound

HRID 1647448Notes

Reaction equation

HRID 1647448 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1.[C:10]([C:15](=[CH:21]OCC)[C:16]([O:18][CH2:19][CH3:20])=[O:17])(=[O:14])[CH2:11][CH2:12][CH3:13]>>[C:10]([C:15](=[CH:21][NH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1)[C:16]([O:18][CH2:19][CH3:20])=[O:17])(=[O:14])[CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 693314-Aminobenzyl alcoholHCID 3359484Ethyl 2-butyryl-3-ethoxyacrylate

Product 1

HCID 178450496HCID 178450496, compound

Procedure

4-Aminobenzylalcohol (25 g) and ethyl 2-butyryl-3-ethoxyacrylate (61 g) were heated together on a rotary evaporator (bath temp 100°) for 30 minutes. Ethyl 2-butyryl-3-(4-(hydroxymethyl)phenylamino)acrylate (49.5 g, 84%) crystallized on standing, was filtered off, washed with a little petroleum ether and vacuum dried, m.p. 44°-6°

Workup

  1. customEthyl 2-butyryl-3-(4-(hydroxymethyl)phenylamino)acrylate (49.5 g, 84%) crystallized
  2. filtrationwas filtered off
  3. washwashed with a little petroleum ether and vacuum
  4. customdried

Sources & evidence

ORD record
ord-cbce1098426f4f74b92c14e8bfb4ddba
Source dataset
uspto-grants-1995_07
Patent number
US05432182

Reaction notes

Loading…