反应详情

Ethyl-2-butyryl-3-(3-benzoyloxymethylphenylamino)-acrylate (34.37 g, 86.9 mmol) was added portionwise to refluxing diphenyl ether (300 ml) then heated at reflux for 1 hour. After cooling, petroleum ether (b.p. 40°-60°) was added, and the precipitated solid filtered off. Purification by column chromatography (silica, methanol-chloroform) gave the title compound as a solid (10.52 g) m.p. 228°-31°, from dichloromethane.

1. temperaturethen heated
2. temperatureat reflux for 1 hour
3. temperatureAfter cooling
4. filtrationthe precipitated solid filtered off
5. customPurification by column chromatography (silica, methanol-chloroform)