Hydrochloric Acid → HCID 19925672, compound

HRID 1647504Notes

Reaction equation

HRID 1647504 reaction equation
[C:1]([C:4]1[CH:25]=[CH:24][C:7]([O:8][CH2:9][CH:10]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][C:15]=3[CH:16]=2)[OH:11])=[CH:6][CH:5]=1)([OH:3])=[O:2].[C:26](OC(=O)C)(=[O:28])[CH3:27].Cl>N1C=CC=CC=1>[C:26]([O:11][CH:10]([C:12]1[O:13][C:14]2[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][C:15]=2[CH:16]=1)[CH2:9][O:8][C:7]1[CH:6]=[CH:5][C:4]([C:1]([OH:3])=[O:2])=[CH:25][CH:24]=1)(=[O:28])[CH3:27]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 15337976HCID 15337976, compound

Product 1

HCID 19925672HCID 19925672, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-[1-Hydroxy-2-(4-hydroxymethylphenoxy)ethyl]-5-isopropylbenzofuran (10 g) obtained in Example 6 was dissolved in 100 ml of pyridine, the mixture was stirred at room temperature for 24 hours with 10 ml of acetic anhydride, poured into ice water, the mixture was acidified with concentrated hydrochloric acid and the crystals separated out therefrom were filtered, dried and recrystallized from ethyl acetate/n-hexane to give 8.2 g of crystals. M.p. 135°-137° C.

Workup

  1. customthe crystals separated out
  2. filtrationtherefrom were filtered
  3. customdried
  4. customrecrystallized from ethyl acetate/n-hexane

Sources & evidence

ORD record
ord-ec6edf13f604401fb0e888a952314d28
Source dataset
uspto-grants-1995_07
Patent number
US05432195

Reaction notes

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