Acetone → Ethanol, 2-[(1-methylethyl)(phenylmethyl)amino]-

HRID 1647552Notes

Reaction equation

HRID 1647552 reaction equation
[NH2:1][CH2:2][CH2:3][OH:4].[CH:5](=O)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(O)C.[H][H].[CH3:18][C:19]([CH3:21])=O>[Pt]>[CH3:18][CH:19]([N:1]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:2][CH2:3][OH:4])[CH3:21]

Participants

7

Reactant 5

HCID 180AcetoneHCID 240BenzaldehydeHCID 700EthanolamineHCID 702EthanolHCID 178418361HCID 178418361, compound2×

Product 1

HCID 11084730Ethanol, 2-[(1-methylethyl)(phenylmethyl)amino]-

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst2×

Procedure

A process according to claim 1 for preparing the compound of the formula ##STR26## which comprises: (a) alkylating 2-aminoethanol using benzaldehyde and ethanol in the presence of a platinum catalyst and hydrogen followed by reductive alkylation using acetone in the presence of a platinum catalyst and hydrogen to give 2-[(1-methylethyl)(phenylmethyl) amino]ethanol;

Workup

  1. customA process according to claim 1 for preparing the compound of the formula ##STR26## which

Sources & evidence

ORD record
ord-876bb00f75fe4c3094bc14ab7808061c
Source dataset
uspto-grants-1995_07
Patent number
US05432284

Reaction notes

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