反应详情

0.6 g of potassium tert-butylate is added to a solution of 1.5 g of 5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one [obtainable by reacting 1-(3,4-dimethoxyphenyl)-2-bromobutan-1-one with methyl hydrazinethioformate] in 30 ml of dimethylformamide (DMF), and the mixture is stirred for 30 minutes. A solution of 3-chloropropyldimethylamine in toluene is then added and the mixture is boiled for three hours. The solvent is removed in vacuo, and the mixture is worked up as usual to give 3-dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 175° (hydrochloride).

1. waitthe mixture is boiled for three hours
2. customThe solvent is removed in vacuo