Methyl iodide → 3-Iodo-4,5-dimethoxybenzaldehyde

HRID 1647742Notes

Reaction equation

HRID 1647742 reaction equation
[I:1][C:2]1[C:3]([OH:12])=[C:4]([O:10][CH3:11])[CH:5]=[C:6]([CH:9]=1)[CH:7]=[O:8].[C:13](=O)([O-])[O-].[K+].[K+].IC>CN(C=O)C>[CH3:11][O:10][C:4]1[CH:5]=[C:6]([CH:9]=[C:2]([I:1])[C:3]=1[O:12][CH3:13])[CH:7]=[O:8]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 79499Benzaldehyde, 4-hydroxy-3-iodo-5-methoxy-

Product 1

HCID 27781133-Iodo-4,5-dimethoxybenzaldehyde

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 5-iodovanillin (7 g, 25.18 mmol), potassium carbonate (8.78 g, 63.53 mmol) and iodomethane (6.43 g, 45.30 mmol) was suspended in 60 mL of DMF and stirred at room temperature for 14 hours. The reaction mixture was quenched with water and extracted with diethyl ether. The organic layer was dried over MgSO4, filtered and evaporated in vacuo to obtain a solid which was recrystallized from hexane/ethyl acetate (2:1) (6.28 g, 85.4%).

Workup

  1. customThe reaction mixture was quenched with water
  2. extractionextracted with diethyl ether
  3. dry with materialThe organic layer was dried over MgSO4
  4. filtrationfiltered
  5. customevaporated in vacuo
  6. customto obtain a solid which
  7. customwas recrystallized from hexane/ethyl acetate (2:1) (6.28 g, 85.4%)

Sources & evidence

ORD record
ord-d72cfbb7c988420d881380327ffd1916
Source dataset
uspto-grants-1995_07
Patent number
US05434151

Reaction notes

Loading…