Hydrochloric Acid → HCID 19968963, compound

HRID 1647762Notes

Reaction equation

HRID 1647762 reaction equation
C(OC([NH:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20]2[C:25]([NH:26][S:27]([C:30]3[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=3)(=[O:29])=[O:28])=[CH:24][CH:23]=[CH:22][N:21]=2)=[CH:15][CH:14]=1)=[O:11])=O)(C)(C)C.[ClH:38]>O1CCCC1>[ClH:38].[ClH:38].[NH2:8][CH2:9][C:10]([O:12][C:13]1[CH:14]=[CH:15][C:16]([NH:19][C:20]2[C:25]([NH:26][S:27]([C:30]3[CH:31]=[CH:32][C:33]([O:36][CH3:37])=[CH:34][CH:35]=3)(=[O:28])=[O:29])=[CH:24][CH:23]=[CH:22][N:21]=2)=[CH:17][CH:18]=1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15293862HCID 15293862, compound

Product 1

HCID 19968963HCID 19968963, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

272 mg (0.515 mmol) of the compound of Example 60 was added to 10 ml of tetrahydrofuran. 2 ml of concentrated hydrochloric acid was added to the mixture and stirred at room temperature for 3 h. The solvent was distilled off under reduced pressure and the residue was recrystallized from ethanol to obtain 159 mg of the title compound.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-22d264b07a654cd2aca1e0b2e40e2dd8
Source dataset
uspto-grants-1995_07
Patent number
US05434172

Reaction notes

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