3-Pyridinecarboxaldehyde → HCID 135491709, compound

HRID 1648217Notes

Reaction equation

HRID 1648217 reaction equation
[CH3:1][C:2]1[NH:11][C:10](=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH:19]=O)[CH:14]=1>C(O)(=O)C>[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH:19]=[CH:1][C:2]2[NH:11][C:10](=[O:12])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH:14]=1

Participants

4

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 1354004572-Methyl-4(3H)-quinazolinone

Product 1

HCID 135491709HCID 135491709, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 2-methylquinazolin-4-one (6.1 g) and 3-pyridinecarbaldehyde (4.1 g) in acetic acid (80 mL) was heated to reflux for 20 hours. After cooling to room temperature, the precipitate was collected by filtration, washed with methanol and dried to obtain the title compound as an acetic acid salt (10.5 g).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 20 hours
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with methanol
  5. customdried

Sources & evidence

ORD record
ord-6fa5af23a148440ebe29a6d8f8488670
Source dataset
uspto-grants-1995_07
Patent number
US05436233

Reaction notes

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