反应详情

Following the procedure of Example 54, but substituting cyclopropylmethyl bromide for iodopropane and 5-(amino)-5,6-dihydro-4H-imidazo[4,5,1 -ij]quinolin-2(1H)-one for 6-bromo-1,2, 3,4-tetrahydro-8-nitro-3-quinolinamine dihydrochloride there were obtained 5-[bis(cyclopropylmethyl)amino]-5, 6-dihydro-4H-imidazo[4,5,1 -ij ]quinolin-2(1H)-one, mp 152-154 from ethyl acetate:hexane and 5 -(cyclopropylmethylamino)-5,6-dihydro-4H-imidazo [4,5,1 -ij]quinolin-2(1H) -one. The latter compound was converted to the hydrochloride salt, mp 309° C. from methanol:ether. ##STR2##