p-Toluenesulfonic acid → HCID 10082813, compound

HRID 1648350Notes

Reaction equation

HRID 1648350 reaction equation
[C:1]1(=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[CH2:12]([NH2:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>O.C1(C)C=CC=CC=1>[CH2:12]([NH:19][C:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 7504BenzylamineHCID 107241-Tetralone

Product 1

HCID 10082813HCID 10082813, compound

Reagents, catalysts & solvents 1

HCID 22272177Toluene waterSolvent

Procedure

A mixture containing 171 mmol of-tetralone, 181 mmol of benzylamine and 100 mg of p-toluenesulfonic acid is brought to reflux with azeotropic distillation of the water/toluene mixture. After 2 hours of distillation, the medium is cooled and filtered. The expected product is obtained in the form of an oil after evaporation of the solvent.

Workup

  1. distillationAfter 2 hours of distillation
  2. temperaturethe medium is cooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-2f1bd10ecf5945bcbcc3ed5f62cbec8b
Source dataset
uspto-grants-1995_07
Patent number
US05436261

Reaction notes

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