反应详情

2-Hydroxy-1-(2-hydroxyethyloxy)benzene (4 g, 26.0 mmol), cyclopropylmethyl-bromide (5.0 g, 37.0 mmol), and potassium carbonate (5.0 g, 36.2 mmol) were combined in acetone (80 mL) and the mixture was refluxed for 18 hours. The mixture was cooled and filtered. The filtrate was evaporated and the residue was dissolved in ether. The solution was washed with water 2N sodium hydroxide, and then brine, and dried over magnesium sulfate. Evaporation gave 2-cyclopropylmethyloxy-1-(2-hydroxyethyloxy)benzene (6.2 g) as an oil.

1. temperaturethe mixture was refluxed for 18 hours
2. temperatureThe mixture was cooled
3. filtrationfiltered
4. customThe filtrate was evaporated
5. dissolutionthe residue was dissolved in ether
6. washThe solution was washed with water 2N sodium hydroxide
7. dry with materialbrine, and dried over magnesium sulfate
8. customEvaporation