Hydrochloric Acid → HCID 19919732, compound

HRID 1648463Notes

Reaction equation

HRID 1648463 reaction equation
[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[C:9]([CH3:11])[C:8]([O:12]COC)=[C:7]([CH3:16])[CH:6]=1)[OH:4].[ClH:17]>O1CCOCC1>[ClH:17].[NH2:1][CH2:2][CH:3]([C:5]1[CH:6]=[C:7]([CH3:16])[C:8]([OH:12])=[C:9]([CH3:11])[CH:10]=1)[OH:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19919746HCID 19919746, compound

Product 1

HCID 19919732HCID 19919732, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 10.55 g of 2-amino-1-(3,5-dimethyl-4-methoxymethoxyphenyl)ethanol [prepared as described in step (b), above] in 200 ml of a 4N solution of hydrogen chloride in dioxane was stirred at room temperature for 18 hours. The solvent was then removed by distillation under reduced pressure, to give 10.45 g of the title compound, melting at between 170° C. and 172° C.

Workup

  1. customThe solvent was then removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-152ef0e10b844401b65283ce9c451033
Source dataset
uspto-grants-1995_07
Patent number
US05436257

Reaction notes

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